Effect of Hydroalcoholic Extract of Perovskia abrotanoides on Glucose, Cholesterol and HDL Levels in Diabetic Rats

Background and purpose: Diabetes mellitus is a highly prevalent disease and there is a global interest in using traditional and herbal medicine in treatment of this disease and other diseases. This study aimed at comparing the effects of hydroalcoholic extract of Perovskia abrotanoides and Glibenclamide on serum glucose, HDL, and cholesterol levels in diabetic rates. Materials and methods: In this experimental study, 70 male Wistar Rats (250-300 g) were divided into seven groups (n=10) and kept under similar conditions. Group I was considered as healthy control and Strptozotosin was used to induce diabetes in groups II-VII. All groups were provided with regular food and water. Group II was considered as diabetic untreated control, Group III was treated by Glibenclamide and groups IV-VII were treated by P. abrotanoide extract at different concentrations. All parameters (serum glucose, cholesterol, and HDL levels) were measured before the study, and at weeks one and four after the study. Results: In groups IV-VII, P. abrotanoid extract significantly decreased serum glucose levels (P<0.05) and cholesterol (P<0.01) and increased HDL-C (P<0.05). Conclusion: This study showed that P. abrotanoid extract has strong antidiabetic and antilipidemic effects and could be used an effective drug in lowering glucose and lipid levels in Streptozocin-induced diabetic rats.